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PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover
https://uec.repo.nii.ac.jp/records/9344
https://uec.repo.nii.ac.jp/records/934461d4bfc0-f81b-460d-a7bc-665c250a747a
名前 / ファイル | ライセンス | アクション |
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s41598-019-40838-6 (8.0 MB)
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Creative Commons Attribution 4.0 International License
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-09-19 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Xie, Min-Jue
× Xie, Min-Jue× Ishikawa, Yasuyuki× Yagi, Hideshi× Iguchi, Tokuichi× Oka, Yuichiro× Kuroda, Kazuki× Iwata, Keiko× Kiyonari, Hiroshi× Matsuda, Shinji× Matsuzaki, Hideo× Yuzaki, Michisuke× Fukazawa, Yugo× Sato, Makoto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The essential involvement of phosphoinositides in synaptic plasticity is well-established, but incomplete knowledge of the downstream molecular entities prevents us from understanding their signalling cascades completely. Here, we determined that Phldb2, of which pleckstrin-homology domain is highly sensitive to PIP3, functions as a phosphoinositide-signalling mediator for synaptic plasticity. BDNF application caused Phldb2 recruitment toward postsynaptic membrane in dendritic spines, whereas PI3K inhibition resulted in its reduced accumulation. Phldb2 bound to postsynaptic scaffolding molecule PSD-95 and was crucial for localization and turnover of PSD-95 in the spine. Phldb2 also bound to GluA1 and GluA2. Phldb2 was indispensable for the interaction between NMDA receptors and CaMKII, and the synaptic density of AMPA receptors. Therefore, PIP3-responsive Phldb2 is pivotal for induction and maintenance of LTP. Memory formation was impaired in our Phldb2−/− mice. | |||||
書誌情報 |
en : Scientific Reports 巻 9, 号 1, p. 4305, 発行日 2019-03-13 |
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出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-019-40838-6 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission fromthe license holder in order to reproduce thematerial. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s41598-019-40838-6 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |